Effect of molecular crowding and confinement experienced by protein in thecell during unfolding has been studied by modeling a linear polymer chain on apercolation cluster. It is known that internal structure of the cell changes intime, however, they do not change significantly from their initial structure.In order to model this we introduce the correlation among the differentdisorder realizations. It was shown that the force-extension behavior forcorrelated disorder in both constant force ensemble (CFE) and constant distanceensemble (CDE) is significantly different than the one obtained in absence ofmolecular crowding.
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